Current Research Grants

Visit Ranjit Bindra's Academic Profile

Agency Grant Name Agency Number
Alex's Lemonade Stand Foundation for Childhood Cancer (ALSF) Small-molecule Screening for Novel Pediatric Glioma Radiosensitizers
YCCI Just-in time Small Pilot Grants Utilizing Core Technologies Development of Novel Methods to Assess DNA Repair Status in Primary Cell Culture Using Next Generation Sequencing
Joanna McAfee Childhood Cancer Foundation Creation of Inducible PAX3/7- FOXO1 Cell Lines for Synthetic Lethal Screening Studies
YCC Pilot High-throughput Screening for K-ras Mutant Cell Tumor Radiosensitizers
YCCC T-TARE DNA Damage Response: The Achilles Heel of HPV-associated HNSCC
The Cure Starts Now/DIPG Collaborative Pre-clinical Development of Novel DIPG Radiosensitizers
Matthew Larson Foundation Creation of Isogenic Pediatric Glioma Cell Lines for High-Throughput Drug Screening Campaigns
NIH/NCI Development of a Novel Assay to Measure DSB Repair at Endogenous Loci in Cells 1 R03 CA194967-01
Yale SPORE in Lung Cancer High-throughput screening for K-Ras mutant tumor cell radiosensitizers
American Cancer Society-Research Scholar Grant Pre-clinical Development of Mibefradil as a Novel Glioma Radiosensitizer 128352-RSG-15-197-01-TBG
Yale Cancer Center Nanoparticle-Encapsulated Radiosensitizers for the Treatment of Glioblastoma Multiforme
Musella Foundation Nanoparticle-Encapsulated Radiosensitizers for the Treatment of Glioblastoma Multiforme
The Pablove Foundation Small Molecule Screening for Novel Rhabdoid Tumor Inhibitors
NIH/NCI Exploiting Mutant IDH1/2-Induced Homologous Recombination Defects in Cancer RO1 CA215453
CureSearch for Children's Cancer Identification of Novel Targeted Agents for Alveolar Rhabdomyosarcoma
Yale Cancer Center 2017- co- Pilot Exploitation of 2-HG conferred vulnerabilities in IDH1/2 mutant MDS/AML in pre-clinical PDX models
Alex’s Lemonade Stand Foundation – Innovation Award Development of nanoparticle-encapsulated chemo/radio-sensitizers for intrathecal delivery
Leukemia and lymphoma Society – Translational Research Program Exploiting mutant IDH1/2-induced BRCAness with PARP inhibitors as a novel AML/MDS therapy

Visit Douglas Brash's Academic Profile

Agnecy Grant Name Agency Number
DOD UVL, ROS, Pigmentation, Genetic Predisposition, and Epigenetic Gene Silencing in Melanoma W81XWH-10-1-0629
NIH Yale SPORE in Skin Cancer 2 P50 CA121674-07
L'Oreal Controlling Chemiexcitation in the Skin: Exploration of Dark CPD Production in Skin
Leo Foundation Chemiexcitation in Human Disease
NIH/NIAMS Chemiexcitation: A New Mode of Skin Disease R01 AR070851

Visit David Carlson's Academic Profile

Agency Grant Name Agency Number
YCCC Non-invasive Imaging of Tumor Hypoxia in Non-small Cell Lung Cancer Patients Undergoing Stereotactic Body Radiotherapy
American Cancer Society Modeling Relative Biological Effectiveness and Oxygen Effects in X-ray, Proton, and Carbon Ion Radiotherapy IRG-58-012-52
Biomedical Advanced Research and Development (BARDA) within the U.S. Department of Health and Human Services In Vivo Biodosimetry using Electron Paramagnetic Resonance (EPR) Spectroscopy HHSO100201100024C

Visit Zhe Chen's Academic Profile

Agency Grant Name Agency Number
NCI Prostate Edema in Permanent Interstitial Brachytherapy 5 R01 CA134627-03

Visit Joseph Contessa's Academic Profile

Agency Grant Name Agency Number
ASTRO Targeting N-Linked Glycosylation to Radiosensitive Malignant Gliomas
YCCI EGFT: Therapeutic Target and Biomarker in NSCLC 5 UL1 RR024139-05
NIH A Bioluminescent Screen for Inhibitors of N-linked Glycosylation 5 R03 DA033178-02
American Cancer Society Institutional Grant Targeting N-linked Glycosylation in Non-Small Cell Lung Cancer ACS #IRG-58-012-56
American Cancer Society Research Scholar Grant Targeting N-linked Glycosylation in Non-Small Cell Lung Cancer
NIH Targeted N-linked Glycosylation to Advance Radiation Therapy 1 R01 CA172391-01A1
NIH Validation of Quantitative 11C-Erlotinib PET for Imaging EGFR-Mutant Lung Cancer 1 R01 CA195493-01
Department of Defense Small Molecule Inhibition of the Oligosaccharyltransferase for the Treatment of Breast Cancer W81XWH-17-1-0066

Visit Roy Decker's Academic Profile

Agency Grant Name Agency Number
Merck Evaluation of Vorinostat in Combination with Palliative Radiotherapy for Patients with Stage IV Non-small Cell Lung Cancer 1 35468
RTOG-Clinical Study Radiation Therapy Oncology Group 1 U10-CA21661
SciClone Pharmaceuticals, Inc. A Phase 2b, Multi-center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Three Different Doses of SCV 07

Visit Jun Deng's Academic Profile

Agency Grant Name Agency Number
NIH/NIBIB Tracking Organ Doses for Patient Safety in Radiation Therapy 1 R01 EB022589-01

Visit Peter Glazer's Academic Profile

Agency Grant Name Agency Number
NIH Hypoxia, DNA Repair and Gene Silencing 5 R01 ES005775-23
NIH Cancer Center Support Grant (CCSG) P30 CA016359-37
NIH Cell-Penetrating Anti-DNA Antibody for Radiosensitization and Cancer Therapy 5 R01 CA168733-05
NIH Bifunctional Antibodies for Melanoma Therapy 5 RO1 CA177719-03
NIH In Vivo Genomic Editing of Hematopoietic Cells for HIV Resistance 5 R01 AI112443-02
NIH Targeted Correction of the Human CFTR Gene 5 R01 HL125892-02
Cystic Fibrosis Foundation Therapeutics Gene Editing Using Nanoparticles with Triplex-Forming PNAs EGAN15XXO
NIH Yale Cancer Biology Training Grant 5 T32CA193200-02
PNA Innovations, Inc Modified PNAs To Develop Gene Editing Therapeutics for Hematopoietic Blood Disorders and Cystic Fibrosis Sponsored Research Award
amfAR, The Foundation for AIDs Research Targeted Inactivation of Integrated HIV Through Host Cell DNA Repair Pathways Investment Grant
FARF Use of Triplex-Forming PNAs as a Strategy for Correction of the FA Phenotype Fanconi Anemia Research Fund Award
NIH/NCI Novel DNA Repair Inhibitors for Cancer Therapy R35 CA197574

Visit James Hansen's Academic Profile

Agency Grant Name Agency Number
Radiological Society of North America (RSNA) Targeting Cancer with Cell Penetrating Anti-DNA Antibody RR1108
American Cancer Society Institutional Grant Investigating Lupus Autoantibody-based Cancer Therapy ACS-IRG #58-012-55
RSNA -Research Scholar Grant Targeting Glioblastoma with a Lupus Autoantibody
YCC 2014 Pilot Targeting KRAS Mutant Cancer Cells with a Lupus Anti-guanosine Antibody
YCCI 2014 Scholar Grant Targeting Cancer with a Lupus Autoantibody
Patrys Limited Deoxymab for Cancer Therapy

Visit Ryan Jensen's Academic Profile

Agency Grant Name Agency Number
American Cancer Society Institutional Grant Biochemical and Genetic Characterization of BRCA2 Sequence Variants ACS-IRG #58-012-55
Breast Cancer Alliance, INC. (BCA) Biochemical and Genetic Characterization of BRCA2 Sequence Variants
Women's Health Research at Yale (WHRY) Biochemical Identification of "BRCAness" in Breast Cancer
Ovarian Cancer Research Fund A "Cellular Switch" to Modulate BRCA2-Mediated Tumor Progression
American Cancer Society-Research Scholar Grant Elucidating Cancer Risk in Homology-directed Repair Variants RSG-17-038-01-01-DMC
NIH/NCI Elucidating Cancer Risk in BRCA2 and RAD51 Variants R01 CA215990

Visit Wu Liu's Academic Profile

Agency Grant Name Agency Number
The Elsa U. Pardee Foundation Radiotherapy: Monte Carlo Dosimetry Modeling
Yale Cancer Center Tumor-Targeted Delivery of Theranostic Gadolinium Nanoparticles

Visit Ravinder Nath's Academic Profile

Agency Grant Name Agency Number
NIH (YCC Core) Cancer Center Core Grant 3 P30-CA16359-32

Visit Abhijit Patel's Academic Profile

Agency Grant Name Agency Number
ASTRO Ultrasensitive Measurement of Tumor DNA in Blood as a Biomarker of Radiation Response JF2011-2
YCCI Circulating Tumor-Derived DNA as a Biomarker for Cancer Treatment Response 5 UL RR024139-05
Brozman Foundation Next-Generation Sequencing for Early Detection of Ovarian Tumor DNA in Blood
American Cancer Society Assessing Cancer Treatment Response by Measurement of Circulating Tumor-Derived DNA
YCC Tumor-Derived Circulating Mutant K-ras DNA as a Biomarker for Radiation Response: A Novel Deep Sequencing Approach
YCCI TARE Tumor DNA in Blood as a Biomarker for Early Detection and Monitoring of Lung Cancer
YCCI - Just-in time Small Pilot Grants Utilizing Core Technologies Tumor DNA in Blood as a Biomarker for Early Detection and Monitoring of Lung Cancer
YCC Pilot Early Detection of New or Recurrent Ovarian Cancer Using Mutant Tumor DNA in Blood
LUNGevity Detection of Early-Stage Lung Cancers via Tumor DNA in Blood
Yale SPORE in Lung Cancer Non-invasive monitoring of mutations in lung cancer via circulating tumor DNA
NIH/NCI Circulating DNA as a Marker of Treatment Efficacy and Failure in Lung Cancer 1 R01 CA197486-01A1
The Honorable Tina Brozman Foundation Early Detection of Ovarian Cancer via Analysis of Genomic Alterations in DNA & RNA from Multiple Sources of Blood
Department of Defense Early Detection of Lung Cancer via Tumor DNA Fragments in Blood W81XWH-16-1-0184
Breast Cancer Alliance, Inc. Profiling of Circulating Tumor Cells to Identify Targets for Adjuvant Therapy in Metastatic Triple Negative Breast Cancer

Visit Sara Rockwell's Academic Profile

Agency Grant Name Agency Number
NIH DNA Repair in Cancer 5 P01 CA129186-05
NIH DNA Repair in Cancer-STIMULUS FUNDS 3 P01 CA129186-04S2
NIH/NCCR Clinical and Translational Science Award (YCCI) UL1 RR 023423

Visit Faye Rogers's Academic Profile

Agency Grant Name Agency Number
NIH Altered Helical Structures: Repair and Induction of Genomic Instability 5 K22 CA120049-03
NIH Altered Helical Structures: Repair STIMULUS FUNDS 3 K22 CA120049-03S1
Breast Cancer Alliance, INC. (BCA) Gene Targeted Apoptosis as a Therapeutic Strategy for HER2-Positive Breast Cancer 278479
YCCC Pilot Novel Therapeutic Strategy for the Treatment of Herceptin Resistant Breast Cancers
NIH/NCI Gene-Targeted Apoptosis as a Treatment for HER2- Positive Breast Cancer 1 R21 CA185192-01A1

Visit Joann Sweasy's Academic Profile

Agency Grant Name Agency Number
NIH-CORE B DiMaio-DNA Polymerase B & Cellular Transformation 3 P01 CA16038-36
NIH Characterization of a DNA Polymerase beta deficient mouse 5 R01 CA116753-05
NIH DNA Polymerase Beta and Breast Cancer 1 R21 CA127097-02
NIH DNA Repair in Cancer 1 P01 CA129186-05
Subcontract - USC DNA Polymerase Fidelity Mechanisms: Theory and Experiment 5 U19 CA10501-08
NIH DNA Polymerase Beta And Mutagenesis-Fidelity 5 R01 CA080830-16
Women's Health Research at Yale Modeling Breast Cancer Treatment in Humanized Mice
YCC Modeling Breast Cancer Treatment in Humanized Mice
NIH DNA Polymerase Beta Variants and Cancer 5 R01 ES019179-03
NIH-UVM Structure and Function of DNA Repair Enzymes 5 P01 CA098993-07
YCCI-TARE The DNA Repair Landscape of Breast Cancer
NIH Characterization of a DNA Polymerase Beta Deficient Mouse 2 R01 CA116753-06A1
NIH Base-Excision Repair and Autoimmunity 1 R21 AI097756-01
YCCI-SPIRIT Uncovering the DNA Repair Landscape in Colon Cancer
NIH Yale SPORE in Skin Cancer 2 P50 CA121974-07
NIH/HIAID The Role of a PARP1 Genetic Variant in Development of Lupus 1 R21 AI124055-01
NIH Assessing the Role of the DNA Repair Landscape in Immune Checkpoint Therapy R21 CA216595
Subcontract – University of Vermont Structure and Function of DNA Repair Enzymes P01 CA098993

Visit Lynn Wilson's Academic Profile

Agency Grant Name Agency Number
NCI Racial Disparities in Clinical Outcomes and the Therapeutic Use of Radiotherapy for Patients with Cutaneous Lymphoma 1 R03 CA151153-01
Stanford Contract A Multicancer, Open-Label, Radomized, Phase I/II Study Evaluating the Safety and Efficacy of Low-Dose (12Gy)Total Skin Electron Beam Therapy (TSEBT) Combined with Verinostat versus Low Dose TSEBT Monotherapy in Mycosis Fungodes (MF) 27136490-50891-B

Visit James Yu's Academic Profile

Agency Grant Name Agency Number
American Cancer Society Institutional Research Grant The PICK Pilot trial: Prostate Intensity Modulated Radiation Therapy versus Cyberknife Health Related Quality of Life (HRQoL) Trial IRG-58-012-52
YCCI Scholar Award Stereotactic Radiosurgery for Older Cancer Patients with Early Stage Non-small Cell Lung Cancer: National Patterns of Care and Comparison with Surgery
21st Century Oncology Research Gift
PhRMA Foundation Foundation Quantifying the Benefit of Modern Cancer Therapy for Elderly Patients: A Population Level Measurement
Yale Cancer Center Reanalyzing the TARGIT-A Trial: A Novel Data Sharing Collaboration

Visit Zhong Yun's Academic Profile

Agency Grant Name Agency Number
NIH Role of Hypoxia in the Regulation of Cancer Cell Differentiation 5 R01 CA125021-05
NIH Epigenetic Regulation in Hypoxic Cancer Cells 1 R01 CA148996-02
YCCI-TARE Stromal Microenvironment and Regulation of Clonal Expansion of Breast Cancer
AHA Adiposed Signaling and Cardiomyopathy 11GRNT7970029
State of CT-STEM Cell Research Grant Hypoxia and Maintenance of Human Cancer Stem Cells
YCC Pilot A Genetic Oxygen-Sensing Mouse Model
NIH Malignant and Radioresistant Nature of Hypoxic Tumor Cells 1 R01 CA178254-01A1
Lion Heart Fund A novel genetic model of tumor hypoxia for breast cancer research